Biologics
TA Instruments | Waters Corporation offers a suite of reliable solutions that are essential for ensuring desired product quality and guaranteeing safety and efficacy in the biopharmaceutical industry. Our Microcalorimetry, Thermal Analysis and Rheology solutions correspond to critical quality attributes (CQAs) that must be carefully measured for all kinds of biotherapeutics, including antibodies, cell and gene therapies, and vaccines. Biotherapeutics, unlike chemically synthesized drugs, can be heterogenous in nature and therefore require rigorous quality testing during development and manufacturing.
Characterization of biopharmaceuticals is accomplished with a panel of technologies to understand their basic chemical details:
Binding affinity, specificity, and stoichiometry (ratio) to the molecular target
Structure stability, and solvent environment stability.
Higher Order Structure (HOS)
Phase transitions
Viscosity and viscoelastic behavior
Residual moisture
Explore solutions from TA Instruments | Waters Corporation for biotherapeutics at different development stages.
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Target Selection
Understanding cellular pathways is important for addressing key questions in life sciences and combating diseases. Target selection involves identifying a…
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Candidate Selectıon & Formulation Development
One of the key goals during candidate selection is ensuring effective binding between the drug and the intended target. Binding assays, such as isothermal…
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Procress Development
Freeze-drying, often called lyophilization, has become a standard process in the pharmaceutical industry for the manufacturing of biologically active…
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Manufacturing & Quality Control
Once a drug formulation passes initial tests, it moves on to manufacturing and quality control evaluation. Manufacturers test critical quality attributes…
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