Composition

An FFF-MALS/DLS system can be further coupled to ICP-MS for elemental analysis. In this approach, the size and relative distribution of the eluting particles are correlated with elemental composition as confirmed by mass spectrometry. This combined technique has been used to examine the size and chemical composition of nanoparticles found in foods as well as the type of metals associated with nanoparticulate fractions recovered from natural sources such as lakes and streams.

The payload of nanodrug delivery particles such as lipid nanoparticles, liposomes or PLGA can be determined by SEC-MALS or FFF-MALS in combination with UV and RI detection. An example is provided in the controlled-release drug-delivery section on this page.