Absolute Molar Mass & Size

Only multi-angle light scattering (MALS) can determine the absolute molar mass and size distributions of heterogeneous polymers independently of retention time and molecular standards, and regardless of non-ideal column interactions. That's because MALS measures molecular weight and rms radius (a.k.a. radius of gyration) directly from first principles. All you need is a convenient means of size-based separation preceding the on-line MALS detector.

Couple a DAWN™ MALS detector and an Optilab™ refractive index concentration detector to your favorite size exclusion chromatography (SEC) or gel permeation chromatography (GPC) system to create a SEC-MALS absolute characterization tool for polymers. Wyatt detectors interface with HPLC systems from all major vendors.

For more advanced separation capabilities consider the advantages of field-flow fractionation coupled to MALS detectors – FFF-MALS. Wyatt's Eclipse™ FFF system separate nanograms to milligrams over sizes from 1 to 1000 nm, without shear or non-ideal column interactions.