Particle size distributions

Particle size, which affects biodistribution and cellular uptake, is one of the most important properties of LNPs. Multi-angle and dynamic light scattering (MALS, DLS) are utilized at different stages of LNP development, production and quality control.

Formulation development & quality control

Rapid screening of formulation conditions to produce LNPs in the desired size range and concentration reduces manual effort, improves product consistency and speeds up time to market. High-throughput DLS using a DynaPro™ Plate Reader measures size and particle concentration in standard 96, 384 or 1536 well plates, providing maximum convenience and lowest consumables cost without sacrificing accuracy or sensitivity.

Accurate characterization of charge and size is essential for evaluating formability. Zeta potential serves as a practical indicator of surface charge, which directly influences cellular uptake and stability. Because pH and ionic strength can dramatically affect surface charge, it’s critical to measure zeta potential under relevant solution conditions.

The DynaPro™ ZetaStar delivers highly precise measurements of zeta potential and size, even in high ionic strength environments while automating analysis for up to 96 samples in a single run. This ensures consistent data quality, minimizes manual effort, and significantly accelerates throughput.