Target & Candidate Proteins
Once target proteins and candidate biomolecules for a given indication have been identified, they must be produced at a small scale in sufficient quantities…
Once target proteins and candidate biomolecules for a given indication have been identified, they must be produced at a small scale in sufficient quantities and appropriate quality for further R&D.
Soluble aggregates
Size exclusion chromatography with multi-angle light scattering (SEC-MALS) accurately characterizes proteins and other biomolecules for soluble aggregates, regardless of non-ideal column interactions, to quickly identify optimal purification conditions.
Stability
High-throughput dynamic light scattering (DLS) using the DynaPro™ Plate Reader requires minimal sample quantities and time to assess candidates and pre-formulation conditions for stability and propensity for aggregation.
Interactions
Composition-gradient, multi-angle light scattering (CG-MALS) combining a Calypso™ composition-gradient system and DAWN™ MALS detector determines affinity and absolute stoichiometry of drug-target binding, without labeling or immobilization. It is particularly well suited for studying multivalent interactions or drug-target binding in the presence of self-association, including virus-like particles (VLPs), monomeric antibodies, oligonucleotides or peptides.
Stabilite