RT-MALS: Process analytical technology (PAT) for AAVs

RT-MALS is a real-time technology for determining empty/full ratio, titer, molar mass and radius. It is valuable in both early- and late stage process environments to monitor quality, collect the appropriate fraction, or flag deviations from acceptable AAV attribute values. RT-MALS is implemented with an ultraDAWN™ MALS instrument and OBSERVER™ software.

Benefits of RT-MALS:

Accelerate process development and scale-up

Increase yield, reduce overall time until lot release

Maintain product quality with confidence

Applications of RT-MALS:

Chromatographic purification and enrichment of full capsids

Concentration of viral vectors by ultrafiltration